Other names: Locus L1
Affected genes: FGF5
Inheritance: autosomal recessive
Mutation: CanFam3.1 32g.4509367G>T c.284G>T
OMIA link: 000439-9615

Appropriate breeds for testing:
Several breeds including: Afghan Hound, Border Collie, Cocker Spaniel, Collie, Corgi, Dachshund, German Shepherd, Golden Retriever, Pomeranian, Samoyed, Shiba Inu

Description:
The L locus impacts canine hair length due to a mutation in the FGF5 gene that prevents FGF5 from functioning as a hair growth termination signal in the hair follicle.

References:
Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, VonHoldt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andre C, Lark KG, Cargill M , Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed by variants in three genes. Science. 2009 Oct; 326(5949):150-3.
Dierks C, Momke S, Philipp U, Distl O. Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. Animation Genet. 2013 Aug; 44(4):425-31.
Housley DJ, Venta PJ. The long and short of it: evidence that FGF5 is a major determinant of canine ‘hair’-itability. Animation Genet. 2006 Aug; 37(4):309-15.