Affected gene: SOD1
Inheritance: Autosomal recessive, incomplete penetrance
Mutation: CanFam3.1 (chr31, exon 2) g.26540342G>A, c.118G>A, p.(E40K)
OMIA link: 000263-9615

Breeds:
Airedale Terrier, American Hairless Terrier, American Pit Bull Terrier, American Staffordshire Terrier/Amstaff, Australian Kelpie, Borzoi, Beagle, German Shepherd, Miniature American Shepherd, Australian Shepherd, Miniature Australian Shepherd, Toy Australian Shepherd, Belgian Shepherd Groenendael, Belgian Shepherd Laekenois , Belgian Shepherd Malinois, Belgian Shepherd Tervueren, White Swiss Shepherd, Anatolian Shepherd, Shetland Shepherd, Finnish Lapland Shepherd, Dutch Shepherd, King Shepherd, Picard Shepherd, Bichon Frize, Biewer Terrier, Bluetick Coonhound, Border Collie, Border Terrier, American Bulldog, English Bulldog, French Bulldog, Australian Mountain Dog, Australian Short Tailed Mountain Dog, Bernese Mountain Dog, Boxer, German Shorthaired Pointer, German Wirehaired Pointer, Bullmastiff, Miniature Poodle, Medium Poodle, Standard Poodle , Pug, Pug Pinscher, Chinese Crested Dog, Friesian Pointing Dog, American Water Dog, Canaan Dog, Pyrenean Mountain Dog, Rhodesian Ridgeback Hound, St. Hubert Hound, Pharaoh Hound, St. Bernard Hound, Finnish Lapland Hound, Catahoula Leopard Hound, Peruvian Hairless Hound, Swedish Lapland Hound, Saarloos Wolfhound, Czechoslovakian Wolf, Chow-chow, Clumber Spaniel, Collie, Shorthaired Collie, Longhaired Collie, Coton de Tulear, Dalmatian, Decker Terrier, Doberman Pinscher, Dogo Argentino, English Coonhound, English Toy Spaniel, Boykin Spaniel, Cavalier King Spaniel Charles, American Cocker Spaniel, English Cocker Spaniel, English Springer Spaniel, Tibetan Spaniel, American Eskimo, Eurasier, Fox Terrier, Wire Fox Terrier, Smooth Fox Terrier, Miniature Fox Terrier, Toy Fox Terrier, American Foxhound, Golden Retriever, Goldendoodle, Wirehaired Pointing Griffon Korthals, Harrier, Hovawart, Siberian Husky, Jack Russell Terrier, Komondor, Koolie, Kuvasz, Labrador Retriever, Laika, Lancashire Heeler, Landseer, English Greyhound, Silkie Hound , Irish Greyhound Dais, Persian Greyhound, Whippet Greyhound, Lucas Terrier, Alaskan Malamute, Maremma Sheepdog, English Mastiff, Mountain Cur, Norfolk Terrier, Norwich Terrier, Old English Sheepdog/Berger anglais/Bobtail, Olde English Bulldogge, Parson Russell Terrier, Patterdale Terrier , German Pinscher, Plott Hound, Portuguese Podengo, English Pointer, Pomeranian/Miniature Spitz, Puli, Pumi, Rat Terrier, Flat-Coated Retriever, Chesapeake Bay Retriever, Nova Scotia Duck Tolling Retriever, Rottweiler, Russell Terrier, Samoyed , Scandinavian Hound, Giant Schnauzer, Miniature Schnauzer, Medium Schnauzer, Sealyham Terrier, Gordon Setter, Irish Setter, Irish Red and White Setter, Shih Tzu, Shiloh Shepherd, Finnish Spitz, Wolf / Keeshond Spitz, Staffordshire Bull Terrier, Tamaskan, Teddy Roosevelt Terrier, Newfoundland, Australian Terrier, Australian Silky Terrier, Boston Terrier, Irish Terrier, Irish Soft Coated Terrier, Kerry Blue Terrier, Tenterfield Terrier, Tibetan Terrier, Treeing Walker Coonhound, Wachtelhund / German Oysel Dog, Welsh Corgi Cardigan, Welsh Corgi Pembroke, Welsh Terrier, Yorkshire Terrier

Symptoms:
Dogs with this condition typically show signs around 8 years of age. Clinical signs include progressive muscle loss and lack of coordination. The disease progresses until the dog can no longer walk. Small breed dogs tend to progress more slowly. In the later stages, affected dogs may become incontinent and the front limbs may be affected. Dogs can lose the ability to walk completely within 6 months to 2 years after the onset of signs. There is currently no effective treatment.

References:
  
Coates, J. R., March, P. A., Oglesbee, M., Ruaux, C. G., Olby, N. J., Berghaus, R. D., O'Brien, D. P., Keating, J. H., Johnson, G. S., & Williams, D. A. (2007). Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs. Journal of Veterinary Internal Medicine, 21(6), 1323. doi: 10.1892/07-059.1
  
Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., Perloski, M., Biagi, T., Baranowska, I., Long, S., March, P. A., Olby, N. J., Shelton, G. D., Khan, S., O'Brien, D. P., Lindblad-Toh, K., & Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences, 106(8), 2794-2799. doi: 10.1073/pnas.0812297106
  
Shelton, G. D., Johnson, G. C., O’Brien, D. P., Katz, M. L., Pesayco, J. P., Chang, B. J., Mizisin, A. P., & Coates, J. R. (2012). Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh Corgis and Boxers. Journal of the Neurological Sciences, 318(1-2), 55-64. doi: 10.1016/j.jns.2012.04.003
  
Zeng, R., Coates, J. R., Johnson, G. C., Hansen, L., Awano, T., Kolicheski, A., Ivansson, E., Perloski, M., Lindblad-Toh, K., O'Brien, D. P., Guo, J, Katz, M. L., & Johnson, G. S. (2014). Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy. Journal of Veterinary Internal Medicine, 28(2), 515-521. doi: 10.1111/jvim.12317