Affected gene: KLKB1
Inheritance: Autosomal Recessive
Mutation: CanFam3.1 16g.44501415A>T c.988T>A
OMIA link: 000819-9615

Appropriate breeds for testing: Shih Tzu

Symptoms:
This disease results from a deficiency of the Fletcher factor, a protein involved in the metabolism of blood coagulation, causing a prolongation of the coagulation time.

References:
Okawa T, Yanase T, Shimokawa Miyama T, Hiraoka H, Baba K, Tani K, Okuda M, Mizuno T. Prekallikrein deficiency in a dog. J Vet Med Sci. 2011 Jan; 73(1):107-11